Stork Enamine Synthesis
Stork Enamine Synthesis Definition:
A Michael reaction in which an enamine functions as a nucleophile.
Stork Enamine Synthesis Explained:
The involvement in addition of an enamine to an alpha, beta-unsaturated carbonyl acceptor in a process similar to the Michael reaction. The product is then hydrolyzed by an aqueous acid to produce a 1, 5-dicarbonyl compound.
How it works:
- formation of an enamine from a ketone
- addition of the enamine to an alpha, beta-unsaturated aldehyde or ketone
- hydrolysis of the enamine back to a ketone