Friedel-Crafts Acylation

Friedel-Crafts Acylation Definition:

An electrophilic aromatic substitution reaction that installs an acyl group on an aromatic ring.

Friedel-Crafts Acylation Explained:

This electrophilic aromatic substitution allows the synthesis of monoacylated products from the reaction between arenes and acyl chlorides or anhydrides. The products are deactivated, and do not undergo a second substitution. Normally, a stoichiometric amount of the Lewis acid catalyst is required, because both the substrate and the product form complex structures.