A compound with the structure R-S-S-R.
Also know as the S-S bond, is a covalent bond made from two thiol groups. By the use of oxidation of sulfhydryl, it can produce stable proteins, dimers, ploymers, or complexes where the sulfide bond can assist in protein folding. It can occur in two ways, Intramolecularly or Intermolecularly.
- Intremolecularly: disulfide bonds occur between polypeptide chains responsible for stabilizing quaternary protein structures.
- Intramolecularly: disulfide occur within the polypeptide chains, responsible for stabilizing tertiary structure of proteins.