Claisen Condensation Definition:
Claisen condensation is defined as a nucleophilic acyl substitution reaction in which the nucleophile is an ester enolate and the electrophile is an ester.
Claisen Condensation Explained:
The carbon bonds form between two esters or one ester with another carbonyl compound while there is a strong base which when combined create a reaction. The mechanism by which this reaction is carried out consists of four stages:
- Deprotination of the alpha position to for na ester enolate.
- The enolate is now a good nucleophile, and attacks an ester.
- The intermediate stabilizes by reforming a carbonyl group, i.e. removing an alkoxide ion.
- The alpha position is again deprotinated to form a double, stable enolate.