Claisen condensation Definition:
Claisen condensation Explained:
The Claisen condensation is the general reaction of enolates with other carbonyl compounds. In the Claisen condensation, two molecules of an ester undergo addition-elimination reactions and they react with each other in the presence of an alkoxide base. This is simply a nucleophilic acyl substitution reaction in which the nucleophile is an ester enolate and the electrophile is an ester. The product of this reaction is a β-keto ester. To prevent transesterification, both the alkoxide and the ester are usually derived from the same alcohol.
Mechanism of Claisen condensation
The mechanism of Claisen condensation begins with the formation of the ester enolate ion. The ester is first deprotonated in the α position to form a resonance-stabilized enolate. Then this enolate function as a nucleophile and attacks another molecule of the ester, forming a