Reaction of Grignards with CO2 Reaction of Grignards with CO2 Definition: Grignard reagents will add to carbon dioxide, forming carboxylate salts. After acidic work-up, carboxylic acids are formed. Reaction of Grignards with CO2 Explained: A Grignard reagent can react with carbon dioxide…
Reaction of Grignards with acid [H+] Reaction of Grignards with acid [H+] Definition: Treatment of Grignard reagents with acid leads to alkanes. Alternatively, use of deuterated acids leads to the resulting deuterated compounds. Reaction of…
Heck Reaction Heck Reaction Definition: The Heck reaction is a coupling reaction of a vinyl or aryl halide with an alkene in the presence of a palladium catalyst which forms a more highly substituted alkene with a new carbon-carbon bond. Heck reaction Explained: The Heck reaction is the…
Haloform reaction Haloform reaction Definition: Addition of a dihalogen (such as iodine, bromine, or chlorine) to a methyl ketone in the presence of base results in a carboxylic acid and a haloform (iodoform, bromoform, or chloroform). Haloform reaction Explained: Haloform reaction is…
Grignard formation [alkyl halides] Grignard formation [alkyl halides] Definition: Treatment of alkyl halides with magnesium metal leads to the formation of Grignard reagent. Grignard formation [alkyl halides] Explained: A Grignard reagent has a formula RMgX where X is a…
Grignard formation [alkenyl halides] Grignard formation [alkenyl halides] Definition: Treatment of an alkenyl halide with magnesium metal leads to the formation of the Grignard reagent. Grignard formation [alkenyl halides] Explained: A Grignard reagent has a formula RMgX where X…
Grignard addition to ketones Grignard addition to ketones Definition: When a ketone is treated with a Grignard reagent, a new carbon-carbon bond is formed at the carbonyl carbon. Subsequent addition of water (acid) will give…
Formation via Grignard and CO2 Formation via Grignard and CO2 Definition: Grignard reagents will add to carbon dioxide, forming carboxylate salts. After acidic work-up, carboxylic acids are formed. Formation via Grignard and CO2 Explained: Carboxylic acids can be prepared…
Formation of organolithium reagents Formation of the organolithium reagents Definition: Addition of lithium metal (2 equivalents) to an alkyl or alkenyl halide results in the formation of the organolithium reagents. Formation of the organolithium reagents Explained: Organolithium reagents have…
Formation of Gilman reagents Formation of Gilman reagents Definition: Alkyl halide will react with lithium metal to make organolithium reagents. When two equivalents of organolithium are combined with a copper halide, this will form organocuprates (Gilman reagents).…