Suzuki Reaction

Suzuki Reaction Suzuki reaction Definition: The reaction of an organic halide with an organoboron reagent in the presence of a palladium catalyst. Suzuki reaction Explained: The Suzuki reaction is a palladium-catalyzed coupling of an organic halide with an organoboron…

Continue Reading

Stille Reaction

Stille Reaction Stille Reaction Definition: Stille reaction is a coupling reaction of an organotin (or organostannanes) with organohalide in the presence of a palladium catalyst. Stille Reaction Explained: Stille reaction is also a coupling reaction (like Heck and Suzuki reactions) which use…

Continue Reading

Reaction of Grignards with CO2

Reaction of Grignards with CO2 Reaction of Grignards with CO2 Definition: Grignard reagents will add to carbon dioxide, forming carboxylate salts. After acidic work-up, carboxylic acids are formed. Reaction of Grignards with CO2 Explained: A Grignard reagent can react with carbon dioxide…

Continue Reading

Reaction of Grignards with acid [H+]

Reaction of Grignards with acid [H+] Reaction of Grignards with acid [H+] Definition: Treatment of Grignard reagents with acid leads to alkanes. Alternatively, use of deuterated acids leads to the resulting deuterated compounds. Reaction of…

Continue Reading

Heck Reaction

Heck Reaction Heck Reaction Definition: The Heck reaction is a coupling reaction of a vinyl or aryl halide with an alkene in the presence of a palladium catalyst which forms a more highly substituted alkene with a new carbon-carbon bond. Heck reaction Explained: The Heck reaction is the…

Continue Reading

Haloform reaction

Haloform reaction Haloform reaction Definition: Addition of a dihalogen (such as iodine, bromine, or chlorine) to a methyl ketone in the presence of base results in a carboxylic acid and a haloform (iodoform, bromoform, or chloroform). Haloform reaction Explained: Haloform reaction is…

Continue Reading

Grignard formation [alkyl halides]

Grignard formation [alkyl halides] Grignard formation [alkyl halides] Definition: Treatment of alkyl halides with magnesium metal leads to the formation of Grignard reagent. Grignard formation [alkyl halides] Explained: A Grignard reagent has a formula RMgX where X is a…

Continue Reading

Grignard formation [alkenyl halides]

Grignard formation [alkenyl halides] Grignard formation [alkenyl halides] Definition: Treatment of an alkenyl halide with magnesium metal leads to the formation of the Grignard reagent. Grignard formation [alkenyl halides] Explained: A Grignard reagent has a formula RMgX where X…

Continue Reading

Grignard addition to ketones

Grignard addition to ketones Grignard addition to ketones Definition: When a ketone is treated with a Grignard reagent, a new carbon-carbon bond is formed at the carbonyl carbon. Subsequent addition of water (acid) will give…

Continue Reading

Formation via Grignard and CO2

Formation via Grignard and CO2 Formation via Grignard and CO2 Definition: Grignard reagents will add to carbon dioxide, forming carboxylate salts. After acidic work-up, carboxylic acids are formed. Formation via Grignard and CO2 Explained: Carboxylic acids can be prepared…

Continue Reading
  • 1
  • 2
Close Menu