Thioether formation RS- Thioether formation (RS‾) Definition: Alkyl halides (or tosylates) will react with thiolate anions to form sulfides (or thioether) in an SN2 reaction. Thioether formation (RS‾) Explained: Nucleophilic substitution at an sp³ hybridized carbon involves…
Thioacetal formation Thioacetal formation Definition: In analogy for the formation of acetals from alcohols and acid, treatment of aldehydes or ketones with thiols in the presence of an acid produces a thioacetal. Thioacetal formation Explained: Sulfur is located in the same group…
Suzuki Reaction Suzuki reaction Definition: The reaction of an organic halide with an organoboron reagent in the presence of a palladium catalyst. Suzuki reaction Explained: The Suzuki reaction is a palladium-catalyzed coupling of an organic halide with an organoboron…
Sulfonylation [SO3/H2SO4] Sulfonylation [SO3/H2SO4] Definition: Treatment of an aromatic molecule such as benzene with sulfur trioxide and strong acid leads to the formation of sulfonic acid in the reaction of electrophilic aromatic substitution. Sulfonylation [SO3/H2SO4] Explained: Concentrated sulfuric acid…
Stork Enamine Reaction Stork Enamine Reaction Definition: The Stork enamine reaction is a method for alkylation or acylation of ketones through intermediates enamines. Stork Enamine Reaction Explained: Ketones cannot be directly alkylated or acylated but when treated with secondary…
Stille Reaction Stille Reaction Definition: Stille reaction is a coupling reaction of an organotin (or organostannanes) with organohalide in the presence of a palladium catalyst. Stille Reaction Explained: Stille reaction is also a coupling reaction (like Heck and Suzuki reactions) which use…
SN2 with Gilman reagents SN2 with Gilman reagents Definition: Alkyl halides (or tosylates) will react with Gilman reagents (organocuprates) to form alkanes in SN2 reaction. SN2 with Gilman reagents Explained: A Gilman reagent is a lithium and diorganocopper reagent compound, R2CuLi (R = alkyl…
SN2 with alkyl halides SN2 with alkyl halides Definition: Nucleophilic bimolecular substitution (SN2) is the general reaction for primary and secondary haloalkanes (alkyl halides) where the halide functions act the leaving group, and…
SN1 Hydride Shift Rearrangement SN1 rearrangement [hydride shift] Definition: The 1,2-hydride shifts can occur during the reactions if an unstable carbocations is formed next to a tertiary carbon. SN1 Hydride Shift Explained: We have already…
SN1 w/ rearrangement [alkyl shift] SN1 w/rearrangement [alkyl shift] Definition: The 1,2-alkyl shift can occur during the substitution reactions if an unstable carbocation is formed adjacent to a quaternary carbon. SN1 rearrangement [alkyl shift] Explained:…